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apalutamide will decrease the extent or influence of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Coadministration of apalutamide, a strong CYP3A4 inducer, with prescription drugs which have been CYP3A4 substrates may result in lower publicity to those remedies.modafinil will boost the le